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The role of steam generator in freeze-drying production


Freeze-drying technology, also known as freeze drying technology, is an advanced process that freezes the material into a solid state and then sublimates the water in the material directly from the solid state to the gas state without passing through the liquid state under a high vacuum environment, thereby achieving drying. This technology is widely used in the fields of pharmaceuticals, food, and biological products because it can retain the original composition, form, and activity of the material to the greatest extent. In the freeze-drying production process, the steam generator plays a key role.In the early stage of freeze drying equipment operation, the steam generator provides heat for preheating the freeze dryer plate layer. During the preheating stage, the steam generator needs to evenly increase the plate temperature from room temperature by 20-30°C in about 30-60 minutes to create suitable initial conditions for pre-freezing the material. Pre-freezing is the basis of freeze drying. Only by accurately controlling the temperature can the material be frozen in a good state, laying the foundation for the subsequent sublimation process.Entering the drying stage, the steam generator becomes the "energy source" for the sublimation of ice crystals of the material. It generates steam with a pressure of about 0.3-0.6MPa and a temperature of 110-130℃ to heat the shelf. By precisely adjusting the steam flow and pressure, the shelf temperature can be accurately controlled at 35-45℃. The stable heat supply allows the moisture of the material to sublimate at a rate of 0.5-1.5kg per hour per square meter of freeze-dried area, ensuring the quality and production efficiency of freeze-dried products.The function of the steam generator is also reflected in the equipment cleaning and sterilization process. During online cleaning (CIP), the high-temperature steam temperature can reach 121°C, the pressure is maintained at 0.2-0.3MPa, and it is continuously flushed for 15-30 minutes, which can effectively remove residual materials and dirt in the equipment; during online sterilization (SIP), saturated steam at 134°C and 0.3MPa is continuously applied for more than 45 minutes, which can achieve a 99.99% killing rate for heat-resistant microorganisms such as thermophilic Bacillus stearothermophilus, ensuring that the equipment is in a clean and sterile state, meeting the strict production hygiene standards of pharmaceuticals and other products, and ensuring product quality and safety.

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The role of steam generator in freeze-drying production

The function of the steam generator is also reflected in the equipment cleaning and sterilization process. During online cleaning (CIP), the high-temperature steam temperature can reach 121°C, the pressure is maintained at 0.2-0.3MPa, and it is continuously flushed for 15-30 minutes, which can effectively remove residual materials and dirt in the equipment; during online sterilization (SIP), saturated steam at 134°C and 0.3MPa is continuously applied for more than 45 minutes, which can achieve a 99.99% killing rate for heat-resistant microorganisms such as thermophilic Bacillus stearothermophilus, ensuring that the equipment is in a clean and sterile state, meeting the strict production hygiene standards of pharmaceuticals and other products, and ensuring product quality and safety.


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